Last year was not a good year for vitamin E.
Suggest the first as a surprise extra for a pill cheaper and safer, heart disease, cancer and Alzheimer's disease, a number of recent clinical trials that could prevent such a thing.
Some even claim there is a small chance that could be harmful at higher doses.
But while the oily little capsule apparently can not keep people living longer, are refused, in part because almost allRecent studies negative for a story or is contradictory to find a glimmer of hope.
Also does not hurt that the dietary supplement industry continues to promote the vitamin E and provide experts to rebut some new research.
"It's not gone," said Edgar Miller, a researcher of vitamin E and professor of medicine at Johns Hopkins University. "Why should we always sell when there are so many of these negative trials?
The answer seems to be a combination ofFactors, including years of promising laboratory, animal and epidemiological studies show a strong promotion for the supplement industry and, more recently, conflicting results of studies, no overall benefit.
The required daily dose is 22 IU (international units). Several recent clinical studies ranged from 300 IU 2000 IU.
Recent clinical studies with high doses of vitamin E, some researchers believe that vitamin E in mega-doses may increase the oxidationLDL-cholesterol, Bad Art
When cholesterol is oxidized, it contributes to coronary artery disease.
There is also some concern that high amounts of vitamin E and other antioxidants are useful to move the food that the average person.
Combining studies
Consider these recent studies: In November, a vitamin-E-bomb by researchers at Johns Hopkins University at a meeting of the American Heart Association has refused.
They have put together 19 clinicalStudies with vitamin E, with 136,000 patients.
In 11 studies of high-level (dosage of 400 IU or more), the risk of death for any reason, increased by 4% compared to those treated with placebo.
Before this statement is that vitamin E, not harmful at worst.
"People taking anti-oxidants, because they want to live longer," said Miller, professor of medicine. "What we have shown is that no longer live."
However, the analysis shows also suggested that low doses of vitamin E(less than 150 IU / day) were associated with the death of about 2% less.
Researchers recognize several potential weaknesses in their study.
She noted that some of the tests of high-dose involve people from various chronic and can not be healthy for people.
They also said that the small size of some controls for analysis and reporting to public health events incompatible prevented a detailed overview of the effects of different doses ofVitamin.
"This is a very bad analysis," said Julie Burying, a professor of medicine at Harvard Medical School, recently presented his research on vitamin E.
He also said not to find the 4% increased risk of death "clinically significant" and could be a possibility.
Women's Health Study
On March 7, burial and other Harvard researchers presented their own studies of vitamin E to American College of Cardiology Annual Meeting.
Again, vitamin –Researchers at a curve.
The analysis of survey data from the Women's Health, a study of 40,000 women who received either 600 IU of vitamin E daily or a placebo, the researchers found that cardiovascular performance was not the whole, such as reducing attacks heart or stroke expected.
However, the analysis found a subgroup of women over 65 years, a 26% reduction of cardiovascular events.
Landfill, said that even if the recognition was "interesting" was not supported previousResearch.
He added that they should be confirmed.
Adding even more confusion, the study showed a statistically significant 24% of cardiovascular deaths among users of vitamin E.
Landfill, that the question is, why there is a reduction in the overall rate of stroke and heart attacks. She said it is possible that this was due to other cardiovascular causes, such as cardiac arrhythmia or heart failure, but there 'was no reasonable explanation for the biologicaldass
"The people the other, but this could be a coincidence, it should look like," he said.
Burying the conclusion that vitamin E is neither harmful nor helpful in the prevention of cardiovascular disease.
A Surprise
About a week after the study of Women's Health, another controversial vitamin E, was presented to find.
The trial involved 9,500 people aged 55 and older with vascular disease or diabetes, followed for seven years on average.
It was found that 400 IU of vitamin EDays did not provide any protection against cancer or major vascular events like heart attack or stroke.
Addition, the study found an alarming increase of 13% for heart failure and 21% increase in hospitalizations for heart failure.
E 'was the first time that vitamin E were associated with an increased risk of heart failure in the relationship, said lead author Eva Lonn, a professor of medicine at McMaster University in Hamilton, Ontario.
"I am not convincedabsorbed from harm, "Lonn.
Indeed, a recent study suggests that young patients with heart failure in a cholesterol-lowering statin, vitamin E actually increased the ability of statins to improve the function of blood vessels and reduce inflammation.
Lonn and other researchers said that a review of all the manifestations of heart failure in large clinical trials of vitamin E "is strongly recommended."
Probability of heart failure has been the recognition, as it seems, aa statistically significant increase of 28% in cases of lung cancer, although in a secondary analysis of data of the advantage seemed to disappear.
"The numbers are small," said Lonnie. "We believe that this is a chance result."
The researchers noted that other large studies of vitamin E were lung cancer showed no benefit.
Alzheimer's Research
There is still some hope that vitamin E may help prevent Alzheimer's disease, although in May in a clinical trial of 769 patients with Mild CognitiveDepreciation found no advantage in delaying progression to Alzheimer's disease.
In this study, the patients for a mega-dose of 2000 IU per day for a maximum of three years have participated, according to results of the New England Journal of Medicine.
More vitamin E / AD studies are ongoing.
The enthusiasm of the 1990s anti-oxidant vitamins will be tempered by clinical studies, according to a JAMA editorial accompanying the Women's Health study results.
"These hopes are nowlimit the modest expectations for specific disorders and there are concerns about the negative impact, "said the editorial.
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